 INTRODUCTION:
The urinary tract includes the kidneys,
the ureters ( the tubes that transport
urine from the kidneys to the bladder).
The urinary tract maintains the chemical
balance of all body fluids and is a
primary system for removal of waste
products. The kidneys are essential
for maintaining the body’s chemical
balance and is therefore a major organ.
A number of kidney disorders are life
threatening and at the less severe level,
disorders such as kidney stones, acute
glomerulonephritis ( temporary inflammation
of a portion of the kidney), bladder
infections and cystitis are extremely
uncomfortable at best. Modern medicine
has no answer except surgery which does
not offer any guarantees. Traditional
medicine however goes to the root cause
of the problems associated with kidney
disorders and cures/prevents these before
they get life threatening or extremely
painful. The kidneys are responsible
for maintaining the quality of blood
that is vital for life. If the toxins
generated by the catabolic process builds
up in the blood, septicemia results
and the death is a real possibility.
THE PRODUCTThe
product offered by AMSAR PVT LTD. is
a result of years of investigation and
study of ethno-botanical data. The herbs
listed here have been used for centuries
in the prevention and cure of kidney
disorders.
COMPOSITION:Each
capsule of AV Uri-K contains standardized
extracts :
RESEARCH:
Crateva
nurvala
In conventional medicine, obstructive
uropathy is still a challenging problem.
The available operative and lithotripsy
procedures are not free from complications
and recurrence of stone formation
is quite common. On the other hand,
in the traditional Indian system of
medicine, several plants are claimed
to be used successfully in the treatment
of urolithasis. The medicinal value
of Crateva nurvala has been described
against a variety of urinary disorders,
including urolithiasis. R Anand et
al have studied these claims and have
reported in their report that the
proprietory extract of the stem bark
of Crateva nurvala showed significant
dose dependant (25-100mg/kg, p.o.)
prophylactic activity against experimentally
induced urolith formation in rats.
The authors also reported that the
drug reversed the biochemical parameters
in urine, blood and serum and brought
back histopathological changes towards
normality.
Y S Prabhakar & D Suresh Kumar
in a separate report have conducted
an exhaustive investigation into the
various activities of Crateva nurvala
and the report shows that the drug
provides significant increase in bladder
tone leading to an increase in the
expulsive force of urination. The
same author has also reported that
the drug had beneficial effects on
neurogenic bladder. These effects
were observed after three months of
therapy. The same author has also
reported that after administration
of the drug for one month, it was
noticed that the excretion of urinary
calcium was reduced to a great extent,
while the excretion of sodium and
magnesium increased significantly.
On plotting the electrolyte values
on a triangular graph, a shifting
of values towards the non-lithogenic
zone was observed. The drug was also
found to alter the relative proportion
of calcium, magnesium and sodium which
precipate in calculus formation.
Prasad et al studied the effect of
an extract of Crateva nurvala stem-bark
in various experimental models. It
was found that it increases the tone
of the smooth muscle intestine and
ureters of guinea pig, dog and humans)
and skeletal muscle (rectii of frog)
in vitro. The PE extract of the bark
inhibited acute, sub-acute and chronic
inflammations in albino rats induced
by carragenin, histamine, croton oil
and formaldehyde. The mechanism of
action was found to be similar to
that of betamethasone, but without
the latter’s side effects. Administration
of 50 ml of stem-bark decoction twice
a day to 46 patients with urinary
stone caused a significant anti-urolithiatric
action. Over a period of between 1-47
weeks, 28 patients were able to pass
the stone, while 18 experienced symptomatic
relief. The spontaneous passing of
stones following C. nurvala therapy
may be facilitated by the tonic contractile
action of the drug on smooth muscle.
Singh, re-examined the lithotritic
action of the stem-bark in patients
suffering from calcium oxalate stones.
After treatment for 12 weeks significant
reduction in pain and dysuria was
noted. There was also some reduction
in the size of the stones
Y S Prabhakar and a co worker investigated
the properties of C Nurvala in the
treatment of urinary stones. The authors
reported that the drug show promise
in the treatment of the disease.
The cytoprotective action of luepol
isolated from C. Nurvala stem bark
against free radical toxicity has
been investigated in experimental
urolithiasis by R Baskar and co workers.
The researchers reported that the
administrating of the drug induced
a remarkable decrease in kidney oxalate
level and was also effective in counteracting
the free radical toxicity by bringing
about a significant decrease in peroxide
levels and increase in antioxidant
status.)
Boerhaavia
diffusa :
Anubha Singh and co workers conducted
a study to investigate the effect
of Boerhaavia diffusa in experimental
acute Pylelonephritis in albino rats.
The authors reported that the drug
was found to be useful in a variety
of renal diseases, they found that
in experimental acute pylelonephritis,
the drug reduced the inflammatory
changes as well as abscess formation
in the kidneys after E.coli inoculation.
It also reduced the bacterial count
in urine samples of the infected animals.
The authors concluded that treatment
with B. Diffusa extract definitely
plays a protective role in renal disorders.
Prof. Vimaladevi at the Dept. of Pharmaceutical
Sciences, Andhra University, Waltair,
investigated the diuretic effect of
Boerhaavia diffusa and phyllanthus
niruri. The author reported that the
mixture was found to be very effective
. The diuretic activity of the plant
is considered to play a vital role
in the elimination of kidney stones
and in the reduction in size of the
stones
H.N. Verma and L.P. Awashti investigated
the anti-viral properties of the plant
and reported that the plant showed
significant inhibitory activity
Shiv pal Singh studied the antileucorrhoeal
activity of the plant and reported
that the continued use of the drug
was very encouraging. 40% of the patients
showed marked improvement and became
almost symptom free within a week
and the other 60% were relieved after
a fortnight. Since Leucorrhoea is
only a symptom of an infection of
the urinary tract, the drug shows
activity against an unspecified infection
Lawsonia
alba :
Lawsonia alba is one of natures most
widely used herbs. The Egyptians have
used it for centuries in cosmetic
applications and it was one of Cleopatra’s
favorite herbs. Traditional medicine
men in India have prescribed this
herb for a variety of diseases and
these claims have been investigated
by a number of modern day researchers.
M.K. Bagi and co workers studied the
pharmacological activity of the herb.
An extract of the herb was found to
have dose dependant analgesic activity
when administered orally.
A Gupta et al studied the anti-inflammatory
activity of some active principles
of Lawsonia leaves. The authors noted
that the drug demonstrated activity
equivalent to phenylbutazone in the
dose of 15mg/kg.
D. Le Mordant & J.P. Forestier
at the Paul Selatier University reviewed
the various uses of the herb in different
schools of traditional medicine, especially
with those pharmaceutical properties
scientifically proven. In a systematic
study, Abd. El Malek showed that the
antibiotic activity of the leaf of
plant was due to 4 compounds. Of these,
Lawsone when tested alone had significant
antibiotic activity, Gallic acid is
a known antiseptic. The authors have
noted in conclusion that the herb
has diverse pharmacological activity.
Tribulus
Terrestris :
R Anand et al, reported that the administration
of ethanolic fraction of Tribulus
terrestris fruit resulted in a varying
degree of reduction is deposition
of stone as compared to the untreated
control animals.
B N Sannd et al undertook a study
to evaluate the effect of the drug
in the management of Urolithiasis.
The authors have reported that the
results of the study were very encouraging
alongwith high rate of symptomatic
relief. The study proved that pathologically
and radiologically 28.57 % of patients
of renal calculi and 75% of patients
of ureteric calculi passed their calculi
completely and in other patients there
was a marked or partial expulsion
of calculi or dislodgement of calculi
or there was a change in shape, size
and consistencies of calculi.
The product also contains other Ayurvedic
herbs that have synergetic action
in various kidney disorders. Several
investigators have shown that the
crude extracts of Bergenia ligulata
had significant activity in dissolving
preformed stones. The proprietory
extract of the plant has marked anti-inflammatory
activity and demonstrates diuretic
action .
INDICATIONS:
- Eliminates calculi
- Restores electrolyte balance
- Fights bacterial infections
- Promotes Kidney tone
DOSAGE:
1 Capsule twice a day till stones
are passed or a week after Urinary
Tract infections have subsided.
CONTRAINDICATIONS:
None reported.
PREGNANCY:
Take under medical supervision.
REFERENCES:
- R. Anand, G.R. Patnaik, D,K, Kulshreshtha,
B.N. Mehrotra, R.C. Srimal and B.N.
Dhawan; Fitoterapia, Vol., LXIV,
No. 4, 1993.
- Deshpande et al Ind. J. Med. Res.,
76, 46-53 (1982)
- Das, P.K., et al J. Res. Ind.
Med., 1:120, 1966
- Singh, R.G. et al. J.Res> Ed.
Ind. Med., 10 : 35 –39, 1991
- Prabhakar, Y.S., & D.Suresh.Kumar,
Fitoterapia, Vol., LXI, No. 2, 1990.
- Baskar,R. Malini, M.M. Varalakshmi,
P. Balakrishna,K. & Bhima Rao,
R., Fitoterapia, Vol. LXVII, No.
2, 1996
- Singh, A. et al, Indian Drugs
26 (1) 1988
- Dr (Mrs) Vimaladevi : a short
communication, Andhra University
- Verma, H.N. & Awasthi L.P.,
National Research Council of Canada,
1979
- Shiv Pal Singh, Ind. J. For. 2(4):
370-371,1979
- Bagi, M.K. et al, Fitoterapia
Vol. LXI, No. 1, 1988
- Gupta, A. et al, Ind. J. Pharmac.
(1986) 18; 113-114.
- D. Le Mordant & J.P. Forestier
at the Paul Selatier, Journ. D’Agric.
Trad. Et de Bota. Appl., XXX, I,
1983
- Anand, R et al, Ind. J. Exp. Biol.,
1994, 32(8): 458-552.
- Sannd, B.N. Kumar, A. Kumar, N.,
J.R.A.S., Vol. XIV, No.,3-4, pp.
98-114
- Selected medicinal plants, CHEMEXCIL,pg
53-54
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