INTRODUCTION

Diabetes is one of the major degenerative disease in the world today. It is a major risk factor for the development of cardiovascular disease. Diabetes is characterized by a reduced ability to use and metabolize dietary carbohydrates, abnormally high blood sugar levels (hyperglycemia) and an abnormal amount of sugar in the urine. Diabetes is classified into 2 categories:

Type 1: Insulin dependent (IDDM) or juvenile-onset diabetes.
Type 2: Non-insulin dependent (NIDDM) or adult-onset diabetes.

IDDM begins suddenly, usually in childhood. It is precipitated by a viral attack on the pancreas, and probably genetic factors. The control of this type of diabetes requires insulin therapy. It is felt that there is no cure for this type.

NIDDM begins after the teen years. The progression is slow compared to IDDM and symptoms are mild in the beginning but becomes severe with the progression. The symptoms of this type is similar to IDDM but the pathology is different. The pancreas contains specialized cells called beta cells that secrete the hormone Insulin in response to high blood sugar levels. In normal conditions, dietary carbohydrates are absorbed from the intestinal lining into the blood as glucose and other simple sugars. As blood levels rise, insulin is secreted from the pancreas and in conjunction with Glucose Tolerance Factor, binds to specialized sites on the membranes of body cells and encourages the transportation of sugar from the blood to the cells. This serves two purposes, it lowers blood sugar and increase availability of sugar(energy) for normal cell functioning. Blood sugar levels return to pre-meal levels as the blood sugar levels decrease.

This process is arrested in diabetic conditions. Blood sugar rises after meals but the pancreas does not secrete adequate amounts of insulin (IDDM) or normal amounts are secreted but the cells are unresponsive to the hormone (NIDDM).

Since the cells are starved of energy, fat is broken down to provide energy to the cells. This raises the blood fat levels increasing the risk of cardio vascular diseases.

How does one recognize Diabetes?
The symptoms are:

• Increased urination
• Dehydration with increased thirst
• Fatigue and muscle weakness
• Nausea and/ or vomiting
• Increased appetite
• Loss of weight(IDDM) or weight gain(NIDDM)
• Frequent skin infections or irritation, slow wound healing
• Itching, tingling and numbness in hands and feet
• Kidney damage
• Visual disturbances
• Cardiovascular disease.

A Blood test ( Fasting and post meal) , Urine analysis should be done if one or more of the above symptoms persist. 

THE PRODUCT:

AV DIASOL is a proprietary formula based on research efforts of the company. It contains herbs that have compelling clinical evidence in the treatment of Type II diabetes. The anti-oxidant activity of the extracts help in preventing further deterioration of beta cells and promotes regeneration.

COMPOSITION:

Each Capsule of Diasol contains extracts of:

• Gymnema sylvestre
• Momordica charantia
• Pterocarpus marsupium
• Trigonella foenum-graecum
• Tinospora cordifolia
• Randia dumetorum

RESEARCH:

Clinical Evaluation of Mormodica chanrantia extract in diabetes

Gymnema sylvetris:
The leaves of Gymnema sylvestris lower blood sugar, stimulate heart and raise urine output . The hypoglycemic activity of leaf powder have been reported both in rabbits and men . Also, leaves of Gymnema syvestris given to diabetics reduce urine sugar level . The hypoglycemic extract of Gymnema sylvestris R.Br. brings about blood glucose homeostasis, which in turn prevents increased glycosylation of proteins thus reversing the onset of changes leading to micro and macroangiopathy. Control of Diabetes mellitus and the associated complications are mediated through the revival or regeneration of the insulin, producing beta -cells in the islets of langerhans .

Eugenia jambolena:
The fruit juice has anti-diabetic activity . Extracts of seed of Eugenia jambolana alleviate glycosuria and Hypoglycemia .

Pterocarpus marsupium:
Pterocarpus marsupium is an anti-diabetic drug . It have been proved to be effective in diabetes by releasing insulin , by regenerating beta cells of islets of langerhans of pancreas .

Trigonella foenum-graecum:
Trigonella foenum-graecum seeds have been shown to possess hypoglycemic properties in both animal and human subjects . The soluble dietary fiber (SDF) when fed simultaneously with glucose showed significant hypoglycemic effect in rats. However, compounds other then SDF is/are also involved in the hypoglycemic activity .

Azadirachta indica:
It has been reported that the aqueous extract of tender leaves of Azadirachta indica tree reduced blood sugar in dogs . Also, its oil, leaf decoction and nimbidin significantly delayed the peak rise in blood sugar after glucose administration. Further, it was found that glucose tolerance test curves are similar to that of Tolbutamide .

Swertia Chirayta:
The plant is bitter with a sharp taste, astringent, tonic, stomachic, lessens inflammation . The extract exhibits hypoglycemic activity .

Shilajit:
Shilajit is employed in diabetes in which it reduces the quantity of sugar and urine .

Cinamomum tamala:
The leaves and bark have been claimed to be effective in the management of diabetes . Oral administration of 50% ethanolic extract of C. tamala leaves significantly lowered the plasma glucose levels in normoglycaemic and streptozotocin hyperglycaemic rats. The extract also exhibited anti hypercholestrimic and antihypertriglyceridemic effects in streptozotocin-hyperglycaemic rats 

Tinospora cordifolia:
Tinospora cardifolia has been proved to be a hypoglycaemic agent .Plant extract caused reduction in fasting blood sugar in rabbits and rats .

Piper Longum:
The ethanolic extract of Piper longum exerted hypoglycaemic effect in rats and also counteracted the spasms induced by various spasmogens in isolated guinea pig ileum.

INDICATIONS:

• Lowers blood sugar levels
• Stimulates the heart
• Reduces sugar in the urine
• Regenerates beta cells
• Binds to dietary fat and removes excess cholesterol
• Promotes regeneration of the pancreas
• Delivers a natural form of insulin called v-insulin.

DOSAGE: 

1 Capsule 30 minutes before meals.

CONTRAINDICATIONS:

Not to be taken with other conventional hypoglycemic products without medical supervision. 

PREGNANCY:

No adverse effects have been reported.

REFERENCES:

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