| INTRODUCTION:
 The
Colon and Rectum
The
colon and rectum are parts of the body's
digestive system, which removes nutrients
from food and stores waste until it passes
out of the body. Together, the colon and
rectum form a long, muscular tube called
the large intestine (also called the large
bowel). The colon is the first 6 feet of
the large intestine, and the rectum is the
last 8 to 10 inches.
Cancer
that begins in the colon is called colon
cancer, and cancer that begins in the rectum
is called rectal cancer. Cancers affecting
either of these organs may also be called
colorectal cancer.
The
exact causes of colorectal cancer are not
known. However, studies show that the following
risk increase a person's chances of developing
colorectal cancer:
- Age:
Colorectal cancer is more likely to occur
as people get older. This disease is more
common in people over the age of 50. However,
colorectal cancer can occur at younger
ages, even, in rare cases, in the teens.
- Diet:
Colorectal cancer seems to be associated
with diets that are high in fat and calories
and low in fiber. Researchers are exploring
how these and other dietary factors play
a role in the development of colorectal
cancer.
- Polyps:
Polyps are benign growths on the inner
wall of the colon and rectum. They are
fairly common in people over age 50. Some
types of polyps increase a person's risk
of developing colorectal cancer. A rare,
inherited condition, called familial polyposis
causes hundreds of polyps to form in the
colon and rectum. Unless this condition
is treated, familial polyposis is almost
certain to lead to colorectal cancer.
- Personal
medical history: Research shows that
women with a history of cancer of the
ovary, uterus, or breast have a somewhat
increased chance of developing colorectal
cancer. Also, a person who has already
had colorectal cancer may develop this
disease a second time.
- Family
medical history: First-degree relatives
(parents, siblings, children) of a person
who has had colorectal cancer are somewhat
more likely to develop this type of cancer
themselves, especially if the relative
had the cancer at a young age. If many
family members have had colorectal cancer,
the chances increase even more.
- Ulcerative
colitis: Ulcerative colitis is a condition
in which the lining of the colon becomes
inflamed. Having this condition increases
a person's chance of developing colorectal
cancer.
Having
one or more of these risk factors does not
guarantee that a person will develop colorectal
cancer. It just increases the chances. People
may want to talk with a doctor about these
risk factors. The doctor may be able to
suggest ways to reduce the chance of developing
colorectal cancer and can plan an appropriate
schedule for checkups.
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THE PRODUCT:
AV
COLEX is a scientifically developed product
that detoxifies the colon and intestines,
clears debris from the digestive process
helps reduce the stress on the intestines
in eliminating and passing digested material
through the length of the system. The process
of purgation depends on the body’s ability
to move digestive wastes through the intestines
without damaging the protective lining.
In many cases where dietary habits are poor,
fibers intake is minimal and stress is a
factor, the body cannot eliminate these
wastes efficiently and they are either retained
in the system crossing the blood tissue
barrier and causing toxicity, or by increasing
the spasmodic process and putting great
strain on the intestinal muscles. AV COLEX
consists of mild purgatives that assist
the body’s natural elimination process whilst
making many of the toxic compounds safe
to transport by chelating them.
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COMPOSITION:
Each
Capusule of AV Colex contains:
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RESEARCH:
Aloe
vera
:
The miracle herb as it is known across the
globe yields a variety of medicinally active
compounds. Amongst the more important compounds
from Aloe vera is a group known as anthraquinones
of which Aloin forms a major part. Aloin
is a proven purgative widely used in the
field of medicine. Aloe contains at least
three anti-inflammatory fatty acids that
are helpful for the stomach, small intestine
and colon. It naturally alkalizes digestive
juices to prevent hyperacidity - a common
cause of indigestion. It helps cleanse the
digestive tract by exerting a soothing,
balancing effect. In a study by Ishii Y
et al, Aloe-emodin-9-anthrone(AE-anthrone),
produced from barbaloin in the rat large
intestine, caused not only an increase in
the intestinal water content but also stimulated
mucus secretion. This might play an important
role in the occurrence of diarrhea. It was
demonstrated that the amount of AE-anthrone
produced in the rat large intestine(maximal
amount: 568 micrograms/rat at 4 h after
injection) was enough to cause both of these
effects, which were observed following intracecal
administration of barbaloin (31.1 mg/kg).
These results together with our previous
data, which showed a relationship between
increase in the intestinal water content
and the stimulation of peristalsis, confirm
that AE-anthrone is the principal agent
responsible for the cathartic effect of
barbaloin. We also propose that the increase
in water content is a more important factor
than stimulation of peristalsis in the induction
of diarrhea by barbaloin. Odes & Madar
conducted a study to evaluate the effect
of a novel laxative preparation, composed
of Aloe vera and other herbal ingredients
in patients with chronic constipation. Thirty-five
men and women were randomized to receive
capsules containing the Aloe vera formula,
or placebo, in a double-blind trial lasting
28 days. Symptoms in the last 2 weeks of
the treatment period were compared to those
in the 14-day pre-trial basal period. In
the Aloe vera group, bowel movements became
more frequent, the stools were softer and
laxative dependence was reduced. In the
placebo group, all these parameters were
unchanged. Abdominal pain was not reduced
in either group. The results of this study
show that the preparation is an effective
laxative in the treatment of constipation.
Tribulus terrestris:
This herb is widely used in India for treating
a variety of disease. Also found in Bulgaria
it is used for impotency. One of the major
medicinal uses is as a urinary cleanser.
It is a diuretic and helps eliminate toxins
from the system.
Trachyspermum
ammi:
This herb is widely utilized as a spice
in Indian cooking. It is used for its flavor
and carminative activity. The fruit of the
plant is antispasmodic as well and a digestive.
The seed, and especially the essential oil
in the seed, is strongly antiseptic, antispasmodic,
aromatic, bitter, diaphoretic, digestive,
diuretic, expectorant and tonic. It is used
internally in the treatment of colds, coughs,
influenza, asthma, diarrhoea, cholera, colic,
indigestion, wind, oedema, arthritis and
rheumatism. The seed is harvested when fully
ripe and either distilled for the essential
oil or dried for later use.
The seed contains about 4 - 6% essential
oil, of which 45 - 55% is the strongly antiseptic
essential oil 'thymol. The essential oil
is also added to cough medicines. The root
is carminative and diuretic.
Cassia angustifolia:
The leaves of the plant yield the most popular
purgative. Sennosides are the most medicinally
active purgatives and used in Modern medicine
across the globe. Two aloe-emodin dianthrone
diglucosides (I and II) were isolated from
the leaves of Cassia angustifolia Vahl by
successive column chromatography with Amberlite
XAD-2, silica gel, Polyamide C-200 and Sephadex
LH-20. The stereostructures of I and II
were elucidated as trans and meso isomers
at 10-10', respectively, from the patterns
of the ultraviolet absorption spectra and
circular dichroism curves. This is the first
report of isolation of diglucoside I from
senna. Despite the lack of purgative activity,
diglucoside I exerts a potentiating effect
of about 1.3 times on the purgative activity
of sennoside A in mice when even 15% is
included in the mixture. The difference
between I and a third active glycoside based
on aloe-emodin is also discussed.
Triphala:
Triphala is a combination of three fruits
Terminalia chebula, Terminalia belerica
and Emblica officinalis. In combination
the fruits produce a mild laxative activity
which synergizes that of the other ingredients.
Ficus carica:
Commonly known a Fig, the fruit of the fig
tree is used in India and the Middle East
as a cure for constipation. Fig extract
has proven to be a mild safe laxative. The
fruit is mildly laxative, demulcent, digestive
and pectoral. The unripe green fruits are
cooked with other foods as a galactogogue
and tonic. Syrup of figs, made from the
fruit, is a well-known and effective gentle
laxative that is also suitable for the young
and very old.
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INDICATIONS:
A Mild , safe laxative that eases bowel
movements. AV Colex provides a natural protection
against colon specific diseases. AV Colex
promotes the smooth evacuation of feces
without disturbing the fluid and electrolyte
balance of the body.
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DOSAGE:
1 to 2 capsules at night before sleeping.
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CONTRAINDICATIONS:
Should not be taken if patient is suffering
from bleeding piles, dysentery & diarrhea.
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PREGNANCY:
Should be avoided during pregnancy.
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REFERENCES:
- Ishii Y, Tanizawa H, Takino Y. Biol
Pharm Bull. 1994 May;17(5):651-3.
- Odes HS, Madar Z, Digestion. 1991;49(2):65-71.
- Ishii Y, Tanizawa H, Takino Y, Chem
Pharm Bull (Tokyo). 1990 Jan;38(1):197-200.
- Nakajima K, Yamauchi K, Kuwano S. J
Pharm Pharmacol. 1985 Oct;37(10):703-6.
- van Gorkom BA, Karrenbeld A, van Der
Sluis T, Koudstaal J, de Vries EG, Kleibeuker
JH Digestion. 2000;61(2):113-20.
- Leng-Peschlow E. Dual effect of orally
administered sennosides on large intestinal
transit and fluid absorption in the rat.
J Pharm Pharmacol 1986;38:606–10.
- Passmore AP, Davies KW, Flanagan PG,
et al. A comparison of Agiolax and Lactulose
in elderly patients with chronic constipation.
Pharmacol 1993;47(suppl 1):249–52.
- Kinnunen O, Winblad I, Koistinen P,
Salokannel J. Safety and efficacy of a
bulk laxative containing senna versus
lactulose in the treatment of chronic
constipation in geriatric patients. Pharmacol
1993;47(suppl 1):253–5.
- Ewe K, Ueberschaer B, Press AG. Influence
of senna, fibre, and fibre+senna on colonic
transit in loperamide-induced constipation.
Pharmacol 1993;47(suppl 1):242–8.
- Valverde A, Hay JM, Fingerhut A, et
al. Senna vs polyethylene glycol for mechanical
preparation the evening before elective
colonic or rectal resection: a multicenter
controlled trial. French Association for
Surgical Research. Arch Surg 1999;134:514–9.
- Gruenwald J, Brendler T, Jaenicke C.
PDR for Herbal Medicines. Montvale, NJ:
Medical Economics, 1998, 722–4.
- Mengs U. Reproductive toxicological
investigations with sennosides. Arzneimittelforschung
1986;36:1355–8.
- Faber P, Strenge-Hesse A. Relevance
of rhein excretion into breast milk. Pharmacol
1988;36(suppl 1):212–20.
- Blumenthal M, Busse WR, Goldberg A,
et al. (eds). The Complete Commission
E Monographs: Therapeutic Guide to Herbal
Medicines. Boston, MA: Integrative Medicine
Communications, 1998, 204–8
- Bown. D. Encyclopaedia of Herbs and
their Uses. Dorling Kindersley, London.
1995
- Chopra. R. N., Nayar. S. L. and Chopra.
I. C. Glossary of Indian Medicinal Plants
(Including the Supplement). Council of
Scientific and Industrial Research, New
Delhi. 1986
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